Tag: polio

The Wellcome Book Prize 2019 Longlist: Reactions & Shadow Panel Reading Strategy

The 2019 Wellcome Book Prize longlist was announced on Tuesday. From the prize’s website, you can click on any of these 12 books’ covers, titles or authors to get more information about them.

 

 

This year marks the 10th anniversary of the prize. As always, it’s a strong and varied set of nominees, with an overall focus on gender and mental health. Here are some initial thoughts (see also Laura’s thorough rundown of the 12 nominees):

  • I correctly predicted just two, Sight by Jessie Greengrass and Heart: A History by Sandeep Jauhar, but had read another three: This Really Isn’t About You by Jean Hannah Edelstein, Amateur by Thomas Page McBee, and Educated by Tara Westover (reviewed for BookBrowse).
  • I’m particularly delighted to see Edelstein on the longlist as her book was one of my runners-up from last year and deserves more attention.
  • I’m not personally a huge fan of the Greengrass or McBee books, but can certainly see why the judges thought them worthy of inclusion.
  • Though it’s a brilliant memoir, I never would have thought to put Educated on my potential Wellcome list. However, the more I think about it, the more health elements it has: her father’s possible bipolar disorder, her brother’s brain damage, her survivalist family’s rejection of modern medicine, her mother’s career in midwifery and herbalism, and her own mental breakdown at Cambridge.
  • Books I knew about and was keen to read but hadn’t thought of in conjunction with the prize: The Trauma Cleaner by Sarah Krasnostein and My Year of Rest and Relaxation by Ottessa Moshfegh.
  • Novels I had heard of but wasn’t necessarily interested in beforehand: Murmur by Will Eaves and Freshwater by Akwaeke Emezi. I went to get Freshwater from the library the afternoon of the longlist announcement and am now 60 pages in. I’d be tempted to call it this year’s Stay with Me except that the magic realist elements are much stronger here, reminding me of what I know of work by Chigozie Obioma and Ben Okri. The novel is narrated in the first person plural by a pair of (gods? demons? spirits?) inhabiting Ada’s head.
  • And lastly, there are a few books I had never even heard of: Polio: The Odyssey of Eradication by Thomas Abraham, Mind on Fire: A Memoir of Madness and Recovery by Arnold Thomas Fanning, and Astroturf by Matthew Sperling. I’m keen on the Fanning but not so much on the other two. Polio will likely make it to the shortlist as this year’s answer to The Vaccine Race; if it does, I’ll read it then.

 

 

Some statistics on this year’s longlist, courtesy of a press release sent by Midas PR:

  • Five novels (two more than last year – I think we can see the influence of novelist Elif Shafak), five memoirs, one biography, and one further nonfiction title
  • Six debut authors
  • Six titles from independent publishers (Canongate, CB Editions, Faber & Faber, Oneworld, Hurst Publishers, and The Text Publishing Company)
  • Most of the authors are British or American, while Fanning is Irish (Emezi is Nigerian-American, Jauhar is Indian-American, and Krasnostein is Australian-American).

 

 

Chair of judges Elif Shafak writes: “In a world that remains sadly divided into echo chambers and mental ghettoes, this prize is unique in its ability to connect various disciplines: medicine, health, literature, art and science. Reading and discussing at length all the books on our list has been fascinating from the very start. We now have a wonderful longlist, of which we are all very proud. Although it sure won’t be easy to choose the shortlist, and then, finally, the winner, I am thrilled about and truly grateful for this fascinating journey through stories, ideas, ground-breaking research and revolutionary knowledge.”

We of the shadow panel have divided up the longlist titles between us as follows (though we may well each get hold of and read more of the books, simply out of personal interest) and will post reviews on our blogs within the next five weeks.

 

Amateur: A true story about what makes a man by Thomas Page McBee – LAURA

Astroturf by Matthew Sperling – PAUL

Educated by Tara Westover – CLARE

Freshwater by Akwaeke Emezi – REBECCA

Heart: A history by Sandeep Jauhar – LAURA

Mind on Fire: A memoir of madness and recovery by Arnold Thomas Fanning – REBECCA

Murmur by Will Eaves – PAUL

My Year of Rest and Relaxation by Ottessa Moshfegh – CLARE

Polio: The odyssey of eradication by Thomas Abraham – ANNABEL

[Sight by Jessie Greengrass – 4 of us have read this; I’ll post a composite of our thoughts]

The Trauma Cleaner: One woman’s extraordinary life in death, decay and disaster by Sarah Krasnostein – ANNABEL

This Really Isn’t About You by Jean Hannah Edelstein – LAURA 

 

The Wellcome Book Prize shortlist will be announced on Tuesday, March 19th, and the winner will be revealed on Wednesday, May 1st.

We plan to choose our own shortlist to announce on Friday, March 15th. Follow along here and on Halfman, Halfbook, Annabookbel, A Little Blog of Books, and Dr. Laura Tisdall for reviews and predictions.

 

Are there any books on here that you’d like to read?

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Final Wellcome Book Prize Shortlist Review: The Vaccine Race by Meredith Wadman

I had hoped this would be a comparable read to Rebecca Skloot’s The Immortal Life of Henrietta Lacks and Siddhartha Mukherjee’s The Emperor of All Maladies, which are two of my absolute favorite books and were also among the first to turn me on to medical-themed literature. Instead, I found myself skimming through the book’s dense scientific and historical information: like Mukherjee’s other book, The Gene, which made last year’s Wellcome shortlist, The Vaccine Race is overstuffed with a mixture of the familiar (for me, at least – genetics), the seemingly irrelevant (cell culture techniques and scientific nomenclature), and the truly interesting (questions of medical ethics).

The unlikely protagonist of this story is Leonard Hayflick, a single-minded and resourceful researcher who is still alive in his late eighties and assented to dozens of interviews and many more e-mails as Wadman put this book together. While in high school Hayflick made a chemistry lab in his basement, and in college he built his father a dental lab: that tells you how driven he was. After graduating from the University of Pennsylvania, he worked at the Wistar Institute on its campus. He chiefly investigated whether viruses cause cancer and whether a cell line will be immortal or subject to the normal rules of aging – the Hayflick limit, named after him, is the number of cell divisions possible before a cell line dies out.

Hayflick experimented on his third child’s placenta, but also on aborted fetuses from the university hospital. Replacement fetal cell lines sourced from the Karolinska Institute in Stockholm, Sweden were used to produce the polio, rubella and rabies vaccines. In particular, he relied on the WI-38 line he developed from fetal cells taken from the Swedish “Mrs. X,” who – like Henrietta Lacks’s family – was never compensated; she did not want to be interviewed for or mentioned by name in this book. In the 1970s, with Roe v. Wade in the pipeline, the controversy over using aborted fetal tissue in research heated up*, and Hayflick was somewhat disgraced in the course of a 1976 lawsuit about his right to profit from WI-38.

But that’s not the only dubious ethical situation associated with the development of the twentieth century’s major vaccines: Hayflick’s bosses and associates had also tested early vaccines on intellectually disabled child “volunteers,” while a celebrated cancer researcher had injected cells into dying hospital patients and healthy prisoners in the name of science. Wadman writes, “by the mid-1960s, ordinary people were becoming less willing to give scientists carte blanche to tinker with human beings on a ‘Trust me, I know what’s best for you’ basis.” The question is whether these morally suspect strategies were worth it, given the alternative: rubella in pregnancy causes severe birth defects including blindness, while polio can be crippling and untreated rabies can lead to a slow and painful death.

These ethical questions are certainly worth thinking about, though the abortion history in particular is probably of much more interest to American readers. Here in Europe, abortion is a non-issue, so I don’t expect anyone to get fired up about the history of fetal tissue research. Wadman is certainly a thorough researcher and capable storyteller who doesn’t talk down when explaining science. That said, she might have scaled back on the science a bit to ensure that her work holds broader appeal for lay readers of popular science and medical history.

*More recently, Debi Vinnedge’s Children of God for Life nonprofit has opposed stem cell research despite a Vatican ruling that vaccines developed from fetal tissue are acceptable to use as long as there is no alternative.

My rating:

 

See what the rest of the shadow panel has to say about this book:

Annabel’s blog tour review: “The thrillerish feel to big pharma’s politics, and Hayflick’s continual battles for recognition and against anyone who wanted to take his cells away from him made for fascinating reading and added the much-needed human aspect.”

Clare’s review: “The Vaccine Race is a very dense read and some of the lengthier descriptions of things like the finer points of the biotechnology industry went a bit over my head in places. … However, the ethical debates are fascinating and clearly presented.”

Laura’s review: “Wadman writes clearly and compellingly, and given how much material she’s handling, managing to structure the book sensibly is a feat in itself. But I felt that The Vaccine Race was often not one thing or the other.”

Paul’s review: “It is a very important story that Wadman is telling … especially given that we may well be on the dawn of a new era in medicine with the rise of immunity against antibiotics.”

(Also, be sure to stop by Paul’s site today for an exclusive extract from The Vaccine Race as part of the ongoing blog tour.)

 

My gut feeling: This is the most science-y of the six books on the shortlist. For me that actually works against the broadness and public-facing nature of the prize, as expressed in its brief: “At some point, medicine touches all our lives. Books that find stories in those brushes with medicine are ones that add new meaning to what it means to be human. The subjects these books grapple with might include birth and beginnings, illness and loss, pain, memory, and identity. In keeping with its vision and goals, the Wellcome Book Prize aims to excite public interest and encourage debate around these topics.”

 

Shortlist strategy:

  • Tomorrow I’ll quickly recap my thoughts about the two shortlisted books I read before the shortlist announcement, With the End in Mind and The Butchering Art.
  • On Saturday morning I’ll announce our shadow panel winner. That day Clare and I are attending an event featuring five of the shortlisted authors in conversation at the Wellcome Collection in London. I’ll report back about it on Sunday.
  • Monday is the awards ceremony, which I’ll be attending for the second year in a row. Expect my write-up of the experience on Tuesday. (In between you get a break from Wellcome Prize stuff with Library Checkout plus some recommendations for May!)