Tag: Joselin Linder

Medical Mysteries: Joselin Linder’s The Family Gene

Yes, another memoir on a medical theme! I really do read a lot of them. My eye was drawn to The Family Gene: A Mission to Turn My Deadly Inheritance into a Hopeful Future by Joselin Linder because of the medical mystery aspect: 14 members of Linder’s Ashkenazi Jewish family are the only known exemplars of their particular genetic disease, so rare it doesn’t have a name or surefire treatment protocol, but now at least has a location on a chromosome.

Linder’s awareness of her family’s peculiar medical problems began when her father, William, himself a doctor near their home in Columbus, Ohio, started having a persistent build-up of lymph (also known as chyle) in his abdomen – usually a sign of heart or liver failure. At one point doctors tapped four liters of the stuff from his lungs. Her father’s illness threw Linder, then a junior in college, for a loop; drugs and music started to replace academics. After he died, aged 49, in September 1996, she became a nomad, moving from Prague to San Francisco to Brooklyn and dabbling in different careers.

Only gradually did they all realize that the same thing had happened to William’s uncle, Nathan, in the 1960s and his grandmother, Mae, before that. While Mae lived to age 54, Nathan died at 34, even after treatment at NIH. Along with the lymphedema, a heart murmur was a common factor. William’s brother, Norman; Linder and her older sister, Hilary; and various cousins of their generation were diagnosed in this way. The author’s own symptoms were initially easily to ignore – swollen ankles and a low platelet count – but escalated in her thirties: a blocked vein in her liver meant she was in danger of bleeding out if she vomited.

It’s rare to be able to trace a genetic disease from its founder through to the present. In Linder’s case, her great-great-grandmother, Ester Bloom, is the first known sufferer. Researchers eventually isolated their family’s gene on the X chromosome, near the location for asthma. This explained why, historically, female family members had a better prognosis than males – they have one normal X chromosome and one diseased one; men only get the defective X chromosome – and why asthma medication helped to an extent.

There are a couple of chapters here on the basics of genetics that felt a little condescending to me; for anyone with a high school or A level biology qualification, the simplistic metaphors explaining the workings of DNA may seem superfluous. I also had trouble relating to Linder’s immediate reaction to her father’s death. Although he’d been severely ill for years by then, her attitude still seems a little heartless. Of the decision to take him off dialysis, she writes, “I was on board. It was time to call it a day.” When the family went around expressing opinions, she said, “I think it’s time, Dad. You’ve been through so much,” to which he replied “F— you”! An ex-boyfriend’s suicide a couple years later affected her much more than her own father’s death. Grief affects people in strange and unpredictable ways, I guess.

What I most appreciated was how the book sensitively reveals the ways a genetic condition complicates life, especially in America: Linder had to do without health insurance for 10 years, having been denied it in Ohio on the grounds of a pre-existing condition. In addition, she and her sister faced a quandary common to those who carry genetic diseases: should they have children? While Hilary underwent pre-implantation genetic diagnosis, a form of IVF, to bear healthy twins, Linder ultimately decided against having children.

I enjoyed the earlier part of this genetic quest narrative a bit more than the later material about Linder’s symptoms. Still, I can recommend this to viewers of House and readers of Susannah Cahalan’s Brain on Fire and the like.


The Family Gene is released by Ecco today. With thanks to Beth Parker and James Faccinto for the electronic review copy via Edelweiss.

My rating:

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Making Plans for March

How is it March already?! The last weekend of February flew by with a trip to Exeter to visit friends. Between Saturday and Sunday we spotted: a humpback whale off the Devon coast at Slapton (occasioning many cries of “Thar she blows!”), a giant pug painted on an underpass, a mighty fine cream tea, and far too many secondhand books at BookCycle.

For me the month of March holds an alarming number of deadlines for book reviews: 15, to be precise. Yipes! Luckily I’ve already managed to submit two of these reviews, and I plan to write a third this afternoon. Most of those are as part of my paid work, but I’ll also be participating in two blog tours for nonfiction books on adoption and foxes, respectively, and contributing a review of Here Comes the Sun by Nicole Dennis-Benn to Shiny New Books.

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As to other planned blog posts for the month…

  • Thanks to your comments I’ve started The Tenant of Wildfell Hall as my monthly classic (27 pages in and I’m loving it already).
  • I’m doing some thematic reading for World Kidney Day on the 9th.
  • I’m thinking of getting my first Haruki Murakami book, The Wind-Up Bird Chronicle, out from the library as my doorstopper of the month.
  • I’ll be reviewing Narcissism for Beginners by Martine McDonagh (terrific) and The Family Gene by Joselin Linder (haven’t started yet).
  • A couple more books may turn up from publishers if I’m lucky.

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Some other themed reading challenges are underway but will probably roll over to future months.

Today I’m picking up three library holds: The Good People by Hannah Kent, The Best of Adam Sharp by Graeme Simsion and Days Without End by Sebastian Barry (this one’s for a BookBrowse review due in April). All are likely to be requested after me, so somehow I have to fit them in during the next three weeks. I do hope they’re quick reads!


So, a busy month – back to the reading! How does the month look for you?