Tag: genetics

Four Recent Review Books: Butler, Hunt, Paralkar and Vestre

Four February–April releases: A quiet novel about the clash of religion and reason; a birdwatching odyssey in London; a folktale-inspired story of the undead descending on an Indian medical clinic; and a layman’s introduction to fetal development – you can’t say I don’t read a wide variety of books! See if any of these tempt you.

 

Little Faith by Nickolas Butler

Butler follows in Kent Haruf’s footsteps with this quiet story of ordinary Midwesterners facing a series of small crises. Lyle Hovde works at a local Wisconsin orchard but is more interested in spending time with Isaac, his five-year-old grandson. Lyle has been an atheist since he and Peg lost a child in infancy, making it all the more ironic that their adopted daughter, Shiloh, has recently turned extremely religious. She attends a large non-denominational church that meets in an old movie theatre and is engaged to Pastor Steven*, whose hardline opinions are at odds with his hipster persona.

Steven and Shiloh believe Isaac has a healing gift – perhaps he can even help Lyle’s old pal, Hoot, who’s just been diagnosed with advanced cancer? The main story line reminded me most of Emily Fridlund’s History of Wolves (health and superstition collide) and Carolyn Parkhurst’s Harmony (the dangers of a charismatic leader). It’s all well and good to have faith in supernatural healing, but not if it means rejecting traditional medicine.

This is the epitome of a slow burner, though: things don’t really heat up until the final 35 pages, and there were a few chapters that could have been cut altogether. The female characters struck me as underdeveloped, but I did have a genuine warm feeling for Lyle. There are some memorable scenes, like Lyle’s heroic effort to save the orchard from an ice storm – a symbolic act that’s more about his desperation to save his grandson from toxic religion. But mostly this is a book to appreciate for the slow, predictable rhythms of a small-town life lived by the seasons.

[*So funny because that’s my brother-in-law’s name! I’ve also visited a Maryland church that meets in a former movie theatre. I was a part of somewhat extreme churches and youth groups in my growing-up years, but luckily nowhere that would have advocated foregoing traditional medicine in favor of faith healing. There were a few false notes here that told me Butler was writing about a world he wasn’t familiar with.]

A favorite passage:

“‘Silent Night’ in a darkened country chapel was, to Lyle, more powerful than any atomic bomb. He was incapable of singing it without feeling his eyes go misty, without feeling that his voice was but one link in a chain of voices connected over the generations and centuries, that line we sometimes call family. Or memory itself.”


With thanks to Faber & Faber for the free copy for review.

 

The Parakeeting of London: An Adventure in Gonzo Ornithology by Nick Hunt

Rose-ringed parakeets were first recorded in London in the 1890s, but only in the last couple of decades have they started to seem ubiquitous. I remember seeing them clustered in treetops and flying overhead in various Surrey, Kent and Berkshire suburbs we’ve lived in. They’re even more noticeable in London’s parks and cemeteries. “When did they become as established as beards and artisan coffee?” Nick Hunt wonders about his home in Hackney. He and photographer Tim Mitchell set out to canvass public opinion about London’s parakeets and look into conspiracy theories about how they escaped (Henry VIII and Jimi Hendrix are rumored to have released them; the set of The African Queen is another purported origin) and became so successful an invasive species.

A surprising cross section of the population is aware of the birds, and opinionated about them. Language of “immigrants” versus “natives” comes up frequently in the interviews, providing an uncomfortable parallel to xenophobic reactions towards human movement – “people had a tendency to conflate the avian with the human, turning the ornithological into the political. Invading, colonizing, taking over.” This is a pleasant little book any Londoner or British birdwatcher in general would appreciate.


With thanks to Paradise Road for the free copy for review.

 

Night Theatre by Vikram Paralkar

This short novel has an irresistible (cover and) setup: late one evening a surgeon in a rural Indian clinic gets a visit from a family of three: a teacher, his pregnant wife and their eight-year-old son. But there’s something different about this trio: they’re dead. They each bear hideous stab wounds from being set upon by bandits while walking home late from a fair. In the afterlife, an angel reluctantly granted them a second chance at life. If the surgeon can repair their gashes before daybreak, and as long as they stay within the village boundaries, their bodies will be revivified at dawn.

Paralkar draws on dreams, folktales and superstition, and the descriptions of medical procedures are vivid, as you would expect given the author’s work as a research physician at the University of Pennsylvania. The double meaning of the word “theatre” in the title encompasses the operating theatre and the dramatic spectacle that is taking place in this clinic. But somehow I never got invested in any of these characters and what might happen to them; the précis is more exciting than the narrative as a whole.

A favorite passage:

“Apart from the whispering of the dead in the corridor, the silence was almost deliberate – as if the crickets had been bribed and the dogs strangled. The village at the base of the hillock was perfectly still, its houses like polyps erupting from the soil. The rising moon had dusted them all with white talc. They appeared to have receded in the hours after sunset, abandoning the clinic to its unnatural deeds.”


With thanks to Serpent’s Tail for the free copy for review.

 

The Making of You: A Journey from Cell to Human by Katharina Vestre

A sprightly layman’s guide to genetics and embryology, written by Doctoral Research Fellow at the University of Oslo Department of Biosciences. Addressed in the second person, as the title suggests, the book traces your development from the sperm Leeuwenhoek studied under a microscope up to labor and delivery. Vestre looks at all the major organs and the five senses and discusses what can go wrong along with the normal quirks of the body.

I learned all kinds of bizarre facts. For instance, did you know that sperm have a sense of smell? And that until the 1960s pregnancy tests involved the death of a mouse or rabbit? Who knew that babies can remember flavors and sounds experienced in utero?

Vestre compares human development with other creatures’, including fruit flies (with whom we share half of our DNA), fish and alligators (which have various ways of determining gender), and other primates (why is it that they stay covered in fur and we don’t?). The charming style is aimed at the curious reader; I rarely felt that things were being dumbed down. Most chapters open with a fetal illustration by the author’s sister. I’m passing this on to a pregnant friend who will enjoy marveling at everything that’s happening inside her.

A representative passage:

“This may not sound terribly impressive; I promised you dramatic changes, and all that’s happened is that a round plate has become a triple-decker cell sandwich. But you’re already infinitely more interesting than the raspberry you were a short while ago. These cells are no longer confused, needy newcomers with no idea where they are or what they’re supposed to do. They have completed a rough division of labour. The cells on the top layer will form, among other things, skin, hair, nails, eye lenses, nerves and your brain. From the bottom layer you’ll get intestines, liver, trachea and lungs. And the middle layer will become your bones, muscles, heart and blood vessels.”


With thanks to Wellcome Collection/Profile Books for the free copy for review.

 

Would you be interested in reading one or more of these?

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Final Wellcome Book Prize Shortlist Review: The Vaccine Race by Meredith Wadman

I had hoped this would be a comparable read to Rebecca Skloot’s The Immortal Life of Henrietta Lacks and Siddhartha Mukherjee’s The Emperor of All Maladies, which are two of my absolute favorite books and were also among the first to turn me on to medical-themed literature. Instead, I found myself skimming through the book’s dense scientific and historical information: like Mukherjee’s other book, The Gene, which made last year’s Wellcome shortlist, The Vaccine Race is overstuffed with a mixture of the familiar (for me, at least – genetics), the seemingly irrelevant (cell culture techniques and scientific nomenclature), and the truly interesting (questions of medical ethics).

The unlikely protagonist of this story is Leonard Hayflick, a single-minded and resourceful researcher who is still alive in his late eighties and assented to dozens of interviews and many more e-mails as Wadman put this book together. While in high school Hayflick made a chemistry lab in his basement, and in college he built his father a dental lab: that tells you how driven he was. After graduating from the University of Pennsylvania, he worked at the Wistar Institute on its campus. He chiefly investigated whether viruses cause cancer and whether a cell line will be immortal or subject to the normal rules of aging – the Hayflick limit, named after him, is the number of cell divisions possible before a cell line dies out.

Hayflick experimented on his third child’s placenta, but also on aborted fetuses from the university hospital. Replacement fetal cell lines sourced from the Karolinska Institute in Stockholm, Sweden were used to produce the polio, rubella and rabies vaccines. In particular, he relied on the WI-38 line he developed from fetal cells taken from the Swedish “Mrs. X,” who – like Henrietta Lacks’s family – was never compensated; she did not want to be interviewed for or mentioned by name in this book. In the 1970s, with Roe v. Wade in the pipeline, the controversy over using aborted fetal tissue in research heated up*, and Hayflick was somewhat disgraced in the course of a 1976 lawsuit about his right to profit from WI-38.

But that’s not the only dubious ethical situation associated with the development of the twentieth century’s major vaccines: Hayflick’s bosses and associates had also tested early vaccines on intellectually disabled child “volunteers,” while a celebrated cancer researcher had injected cells into dying hospital patients and healthy prisoners in the name of science. Wadman writes, “by the mid-1960s, ordinary people were becoming less willing to give scientists carte blanche to tinker with human beings on a ‘Trust me, I know what’s best for you’ basis.” The question is whether these morally suspect strategies were worth it, given the alternative: rubella in pregnancy causes severe birth defects including blindness, while polio can be crippling and untreated rabies can lead to a slow and painful death.

These ethical questions are certainly worth thinking about, though the abortion history in particular is probably of much more interest to American readers. Here in Europe, abortion is a non-issue, so I don’t expect anyone to get fired up about the history of fetal tissue research. Wadman is certainly a thorough researcher and capable storyteller who doesn’t talk down when explaining science. That said, she might have scaled back on the science a bit to ensure that her work holds broader appeal for lay readers of popular science and medical history.

*More recently, Debi Vinnedge’s Children of God for Life nonprofit has opposed stem cell research despite a Vatican ruling that vaccines developed from fetal tissue are acceptable to use as long as there is no alternative.

My rating:

 

See what the rest of the shadow panel has to say about this book:

Annabel’s blog tour review: “The thrillerish feel to big pharma’s politics, and Hayflick’s continual battles for recognition and against anyone who wanted to take his cells away from him made for fascinating reading and added the much-needed human aspect.”

Clare’s review: “The Vaccine Race is a very dense read and some of the lengthier descriptions of things like the finer points of the biotechnology industry went a bit over my head in places. … However, the ethical debates are fascinating and clearly presented.”

Laura’s review: “Wadman writes clearly and compellingly, and given how much material she’s handling, managing to structure the book sensibly is a feat in itself. But I felt that The Vaccine Race was often not one thing or the other.”

Paul’s review: “It is a very important story that Wadman is telling … especially given that we may well be on the dawn of a new era in medicine with the rise of immunity against antibiotics.”

(Also, be sure to stop by Paul’s site today for an exclusive extract from The Vaccine Race as part of the ongoing blog tour.)

 

My gut feeling: This is the most science-y of the six books on the shortlist. For me that actually works against the broadness and public-facing nature of the prize, as expressed in its brief: “At some point, medicine touches all our lives. Books that find stories in those brushes with medicine are ones that add new meaning to what it means to be human. The subjects these books grapple with might include birth and beginnings, illness and loss, pain, memory, and identity. In keeping with its vision and goals, the Wellcome Book Prize aims to excite public interest and encourage debate around these topics.”

 

Shortlist strategy:

  • Tomorrow I’ll quickly recap my thoughts about the two shortlisted books I read before the shortlist announcement, With the End in Mind and The Butchering Art.
  • On Saturday morning I’ll announce our shadow panel winner. That day Clare and I are attending an event featuring five of the shortlisted authors in conversation at the Wellcome Collection in London. I’ll report back about it on Sunday.
  • Monday is the awards ceremony, which I’ll be attending for the second year in a row. Expect my write-up of the experience on Tuesday. (In between you get a break from Wellcome Prize stuff with Library Checkout plus some recommendations for May!)

Medical Mysteries: Joselin Linder’s The Family Gene

Yes, another memoir on a medical theme! I really do read a lot of them. My eye was drawn to The Family Gene: A Mission to Turn My Deadly Inheritance into a Hopeful Future by Joselin Linder because of the medical mystery aspect: 14 members of Linder’s Ashkenazi Jewish family are the only known exemplars of their particular genetic disease, so rare it doesn’t have a name or surefire treatment protocol, but now at least has a location on a chromosome.

Linder’s awareness of her family’s peculiar medical problems began when her father, William, himself a doctor near their home in Columbus, Ohio, started having a persistent build-up of lymph (also known as chyle) in his abdomen – usually a sign of heart or liver failure. At one point doctors tapped four liters of the stuff from his lungs. Her father’s illness threw Linder, then a junior in college, for a loop; drugs and music started to replace academics. After he died, aged 49, in September 1996, she became a nomad, moving from Prague to San Francisco to Brooklyn and dabbling in different careers.

Only gradually did they all realize that the same thing had happened to William’s uncle, Nathan, in the 1960s and his grandmother, Mae, before that. While Mae lived to age 54, Nathan died at 34, even after treatment at NIH. Along with the lymphedema, a heart murmur was a common factor. William’s brother, Norman; Linder and her older sister, Hilary; and various cousins of their generation were diagnosed in this way. The author’s own symptoms were initially easily to ignore – swollen ankles and a low platelet count – but escalated in her thirties: a blocked vein in her liver meant she was in danger of bleeding out if she vomited.

It’s rare to be able to trace a genetic disease from its founder through to the present. In Linder’s case, her great-great-grandmother, Ester Bloom, is the first known sufferer. Researchers eventually isolated their family’s gene on the X chromosome, near the location for asthma. This explained why, historically, female family members had a better prognosis than males – they have one normal X chromosome and one diseased one; men only get the defective X chromosome – and why asthma medication helped to an extent.

There are a couple of chapters here on the basics of genetics that felt a little condescending to me; for anyone with a high school or A level biology qualification, the simplistic metaphors explaining the workings of DNA may seem superfluous. I also had trouble relating to Linder’s immediate reaction to her father’s death. Although he’d been severely ill for years by then, her attitude still seems a little heartless. Of the decision to take him off dialysis, she writes, “I was on board. It was time to call it a day.” When the family went around expressing opinions, she said, “I think it’s time, Dad. You’ve been through so much,” to which he replied “F— you”! An ex-boyfriend’s suicide a couple years later affected her much more than her own father’s death. Grief affects people in strange and unpredictable ways, I guess.

What I most appreciated was how the book sensitively reveals the ways a genetic condition complicates life, especially in America: Linder had to do without health insurance for 10 years, having been denied it in Ohio on the grounds of a pre-existing condition. In addition, she and her sister faced a quandary common to those who carry genetic diseases: should they have children? While Hilary underwent pre-implantation genetic diagnosis, a form of IVF, to bear healthy twins, Linder ultimately decided against having children.

I enjoyed the earlier part of this genetic quest narrative a bit more than the later material about Linder’s symptoms. Still, I can recommend this to viewers of House and readers of Susannah Cahalan’s Brain on Fire and the like.


The Family Gene is released by Ecco today. With thanks to Beth Parker and James Faccinto for the electronic review copy via Edelweiss.

My rating: